Revised 29 Jul S2 Table. Acromegaly, or too much growth hormone, causing body tissues grow larger over time. Vermeulen, L. Hernandez-Boussard, J. The role of sex hormone-binding globulin SHBGtestosterone, and other sex steroids, on the development of type 2 diabetes in a cohort of community-dwelling middle-aged to elderly men.
The New England Journal of Medicine. In men, low serum SHBG levels are associated with insulin resistance [ 3 ], obesity [ 4 ], non-alcoholic fatty liver disease NAFLD [ 5 ], type 2 diabetes T2D [ 67 ], and cardiovascular disease [ 7 ].
Testosterone, SHBG and differential white blood cell count in middle-aged and older men. Rastrelli, M. This is an open access article distributed under the terms of the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Characteristics of the study participant at baseline and 5- year follow-up.
MetS is associated with a twofold increase in cardiovascular disease CVD risk and a nearly fivefold increased risk of type 2 diabetes . Molecular Endocrinology. SHBG is found in all vertebrates apart from birds.
Humana Press. Odds ratios and hazard ratios for individual metabolic syndrome components per quartile decrease of total testosterone, SHBG and free testosterone.
The longitudinal models fitted serum SHBG at follow-up median 4. Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts. C-reactive protein Lactalbumin Alpha-lactalbumin Parvalbumin Ricin.
Obesity is a risk factor for hypogonadotropic hypogonadism in men.